Using the Feeding RNAi and Compound-protein Interaction Profile to Identify the Drug Target of Annon

来源 :第八届中国蛋白质组学大会 | 被引量 : 0次 | 上传用户：wangfuqun

【摘要】

：

Annonaceous acetogenins are a family of natural products with antitumor activities.The polyether mimic AA005 has recently beenfound to have the ability of inducing cancer cell death via suppression of

【作者】

：

Bing Han Li-Ying Huang hao-Xia Wu San-feng Han Hui-Zi Wang Tong-Dan Wang Li Xia Ling-Xiao Wang Li-Shun Wang

【机构】

：

Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education,Rui-Jin Hospi

【出处】

：

第八届中国蛋白质组学大会

【发表日期】

：

2013年11期

【关键词】

：

Annonaceous acetogenins lipid accumulation HADHA mitochondria

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

调控天然免疫系统促进丙肝病毒在人胚胎干细胞来源的肝脏细胞中的感染和复制

肝炎性病毒感染严重影响着人类生命健康,但迄今仍缺乏能真实反映病毒与宿主之间相互作用的研究模型。建立能够真实反映肝炎性病毒与人肝脏细胞相互作用的细胞模型对肝炎性病毒致病机制和抗病毒新药的开发具有重要意义。我们开展了应用人胚胎干细胞定向分化获得的肝脏细胞建立肝炎病毒感染模型的研究,成功的应用人胚胎干细胞建立了HCV感染复制体外模型,该模型能够支持HCV完整的生命周期(包括新产生病毒的释放)。研究发现H

会议

丙型肝炎病毒(HCV)人胚胎干细胞肝脏细胞感染复制

人胚胎干细胞来源的肝细胞:一种具有潜力的乙肝病毒研究模型

随着干细胞技术的发展,应用干细胞建立疾病模型为相关疾病致病机制的研究提供了新的契机。我们初步探索了应用人胚胎干细胞来源的肝细胞作为乙肝病毒(H3v)体外研究模型的潜力。定向分化人胚胎干细胞为肝细胞(hESC-Heps)；采用免疫荧光方法检测肝性因子如肝细胞核因子-4α(HNF4α)、白蛋白(ALB)和HBV功能性受体钠离子/牛磺胆酸共转运蛋白(NTCP)受体的表达；实时荧光定量PCR检测Ⅲ型干扰素

会议

人胚胎干细胞肝细胞HBV研究模型

Cell Death-inducing DFFA-like Effector B Regulated by PGC-1(α and HNF4α Interacts with Hepatitis C V

Hepatitis C virus (HCV) hijacks host lipid metabolism for its infection.However, this mechanism remains poorly understood.We previously reported that HCV replication requires hepatocyte nuclear factor

会议

HCVCiDeBPGC-1αHNF4αlipid metabolism

Effect of RNAi Targeting CLIC1 on the Physiological Function of Lung Adenocarcinoma Cells

Human lung adeno-carcinoma is one of the most aggressive cancers in the world,with a high incidence and mortality rate.The major obstacle in the field is the late diagnosis due to the highly heterogen

会议

proteomicsCLIC1RNAilung adenocarcinomaproliferationmetastasisinvasion

Novel Proteomic Tools to Study Molecular Signaling

Protein phosphorylation plays a critical role in the regulation of many cellular functions.Analysis of phosphoproteomes by mass spectrometry depends on many factors,in particular an efficient method t

会议

Quantitative Proteome Analysis of Cell Surface Proteins Involved in Astrocytic Differentiation of Ne

The neural potential of pluripotent neural stem cells (NSCs) makes them a promising source for cell-based therapy of neural tissue damage.However,the exact intracellular molecular mechanisms of neural

会议

Neural Stem CellAstrocytic differantiationSILACTandem mass spectrometry

Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiqui

Protein acetylation has emerged as a major mechanism in regulating cellular metabolism(1-3).Whereas most glycolytic steps are reversible,the reaction catalyzed by pyruvate kinase is irreversible and t

会议

Identification and Verification of Lysine Succinylation as a Novel in-vivo Protein Post-Translationa

Of the 20 ribosomally coded amino acid residues,lysine is the most frequently post-translationally modified,which has important functional and regulatory consequences.Here we report the identification

会议

lysinelysine succinylationprotein post-translational modificationPTMapsuccin

High-throughput N-glycopeptide Profiling in Serum

Glycosylation is one of the most important and common forms of protein posttranslational modifications,which is involved in many physiological functions and biological pathways.

会议

Characterization of N-glycosylation in the Extracellular Region of CD44s and Exploration of Its Reco

CD44 is type-1 transmembrane glycoprotein mediating the response of cells to their cellular microenvironment (1).CD44 proteins participate in many cellular processes,including the regulation of growth

会议

Using the Feeding RNAi and Compound-protein Interaction Profile to Identify the Drug Target of Annon

与本文相关的学术论文