【摘 要】
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Directional cell migration and tumor invasion requires the tight coordination of actin assembly and plasma membrane remodeling, which is orchestrated by gro
【机 构】
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DepartmentofBiologyUniversityofPennsylvaniaPhiladelphia,PA19104-6018U.S.A.
【出 处】
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第四届吴宪吴瑞国际学术研讨会、第九届全国医学生物化学与分子生物学、第六届全国临床应用生物化学与分子生物学联合学术讨论会
论文部分内容阅读
Directional cell migration and tumor invasion requires the tight coordination of actin assembly and plasma membrane remodeling, which is orchestrated by growth factor signaling.However, the molecular mechanism underlying this coordination remains elusive.The exocyst is an evolutionarily conserved octameric protein complex that regulates secretory vesicle docking and fusion during exocytosis.Recent studies demonstrate a role of the exocyst in cell migration and tumor invasion.In particular,Exo70, a component of the exocyst complex,directly interacts with the Arp2/3 complex, and kinetically stimulates actin polymerization and branching at the plasma membrane.In addition,Exo70 physically induces membrane curvature and generates protrusions on the surface of cells.
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