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Contents 1.Brief history of pharmacometrics in China 1979-2000: PD, PK, statistical model 2000-2015: PPK, PK-PD, MBMA 2.China status of pharmacometrics only presented by our team works PK-PD: Parameterized PK-PD modeling MBMA: Model based meta analysis 3.Opportunity and challenge of pharmacometrics in China Guidance published by CFDA Ex post modeling Early involvement (trial design, modeling & simulation)