【摘 要】
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Background, Motivation and Objective We previously examined micro-scale interactions of ultrasound stimulated microbubbles (USMBs) with fibrin clots, gaining direct evidence of the ability of MBs to e
【机 构】
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Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada
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Background, Motivation and Objective We previously examined micro-scale interactions of ultrasound stimulated microbubbles (USMBs) with fibrin clots, gaining direct evidence of the ability of MBs to enter clots and, depending on MB size and exposure condition, damage the fibrin network and promote fluid uptake [Acconcia et al APL 2013; UMB 2014].This work also illustrated the role of radiation forces, namely translation of MBs toward the clot, their possible coalescence, and interactions at the surface of and within clots.While current mechanistic theories focus on the effect of exposure schemes on MB-clot interactions, here we hypothesize that a key aspect of an exposure scheme is its impact on how MBs are brought to the clot boundary and their subsequent interactions.
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