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It has been over 135 years since Sir Lauder Brunton proposed the use of amyl nitrate for the therapy of angina pectoris.Amyl nitrate of course acts as an exogenous donor of nitric oxide (NO).NO or EDRF plays a crucial role in physiologic regulation of different tissues in the human body.In addition NO has been shown to have diagnostic and therapeutic benefits as a drug.This is administered in the form of an inhaled gas.The response to inhaled NO has been shown to predict a favorable clinical response to vasodilators in patients with primary hypertension and is the main stay of such testing.