Nanobody is a class of camelid-derived single-domain antibody that has many potential advantages over conventional antibody and has been utilized to develop new therapeutic strategies for cancer and o
FTO,the first m6A demethylase,has been associated to promote leukemogenesis and other cancers.We identified meclofenamic acid(MA)selectively inhibits FTO demethylation over ALKBH5.
The islet of Langerhans is the most important organ for glucose homeostasis.It is majorly composed of alpha cells secreting glucagon and beta cells secreting insulin.Although alpha cell is an end-diff
Currently,more than 200 fecal microbiota transplantation(FMT)clinical trials have been completed or ongoing worldwide,but our understanding of FMTs mechanism is very limited.
Thioamide substitution has evolved into an important tool for the chemical biology of peptides and proteins.[1] However,exploration of its full potential has been hampered by insufficient synthetic st