论文部分内容阅读
鼻咽癌是一种多基因遗传性恶性肿瘤,在我国南方发病率极高,严重危害了我国南方地区人民生命健康。鼻咽癌的发生发展是多因素、多途径的演变过程,多个癌基因和抑癌基因的突变失活参与其中。目前研究发现鼻咽癌与COX-2、PCNA、uPARAP、MMP9、HGF/c-Met、E-cadherin/P120ctn、RAGE、P-Akt、p73、ANXA1、p14ARF、Sur-vivin、Kiss-1、l4-3-3σ等基因相关,通过对这些基因结构和功能的深入研究,将为鼻咽癌的临床诊治和预防提供新的途径,对人类战胜鼻咽癌有着极其重要的意义。
Nasopharyngeal carcinoma is a multi-gene hereditary malignant tumor with a very high incidence in southern China, which has seriously endangered the lives and health of people in southern China. The occurrence and development of nasopharyngeal carcinoma is a multi-factor, multi-pathological evolution process, in which mutations of multiple oncogenes and tumor suppressor genes are involved. The present study found that the expression of COX-2, PCNA, uPARAP, MMP9, HGF / c-Met, E-cadherin / P120ctn, RAGE, P-Akt, p73, ANXA1, p14ARF, Survivin, Kiss-1, -3-3σ and other genes related to the structure and function of these genes through in-depth study for the clinical diagnosis and treatment of nasopharyngeal carcinoma provide a new way for human beings is extremely important to the victory over nasopharyngeal carcinoma.