【摘 要】
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Surface-enhanced Raman scattering(SERS)has become one of the most valuable tools in chemistry,biology and materials science.1 In particular,by integrating t
【机 构】
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SchoolofChemistryandBiologicalEngineering,ChangshaUniversityofScienceandTechnology,Changsha,410004Co
【出 处】
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2016年分析化学前沿国际研讨会及中美分析化学研讨会
论文部分内容阅读
Surface-enhanced Raman scattering(SERS)has become one of the most valuable tools in chemistry,biology and materials science.1 In particular,by integrating the extremely strong Raman enhancement of functional nano-substrates and the highly specific recognition ability of biomolecules,SERS has been used to create many novel bioanalytical tools,such as DNA sequence detection,protein assay,and bacterial or pathogen identification.2 In the recent years,we aim to develop SERS amplification assays of nucleic acids and proteins combing with triplex-molecular switch and nanomaterials,which include:1)Combing with DNA nanomachine-functionalized silver nanoparticles to construct reversible and regenerable SERS-active substrate,and thus attain ultrasensitive biomolecules sensing.3-5 2)Integrated with carbon nanomaterials to achieve microRNA and ATP detection.6-7 3)Inspired by the ions-mediated cascade amplification,we realize single nucleotide polymorphism and telomerase detection.8 These new SERS amplification assays might open up new opportunities in the application of functional nucleic acid in biosensing.
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