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目的 ToexploretheroleoftheCD40/CD40Lpathwayindendriticcellregulation,Tc1celldifferentiationinmousemodelsofemphysemawasinducedbycigarettesmoke(CS)方法 C57BL/6JmiceandCD40-deficientmicewereexposedtosmokeorairforupto24weeks.ThedistributionanddifferentiationofTc1cellsinthesemicewereinvestigated.Lungdendriticcellsdistributionandtheircostimulatorymoleculesawerealsoinvestigated.