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Objective Ghrelin, a natural ligand for the growth hormone secretagogue receptor 1a (GHS-Rla), is mainly secreted from stomach with smal1 amounts produced in the brain.The expression of GHS-Rla in the dopaminergic neurons of substantia nigra (SN) indicates that SN might be a target site of ghrelin.We previously reported that ghrelin could protect dopaminergic neurons through GHS-R1a against neurotoxicity by inhibiting apoptosis, attenuating oxidative stress and enhancing the cell excitability.However, the role of ghrelin in motor coordination is largely unknown.The present study aims to explore the effects of intranigral injection of ghrelin on haloperidol-induced catalepsy in rats.Methods Cannula-embedding technique, intranigral injection, postural and bar test were used.Results (1) Unilateral microinjection of ghrelin (1000 nmol/L) into the SN induced a contralateral dystonic posturing in the haloperidol-induced catalepsy rats.In the control group, saline injection into the SN did not cause any fixed deviated posturing in the haloperidol-induced catalepsy rats.(2) Microinjection of 1000 nmol/L ghrelin into the SN was able to attenuate the descent latency in the presence of systemic haloperidol administration.Conclusion Ghrelin is capable of attenuating haloperidol-induced catalepsy and regulating the motor function of SN.