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Introduction: Serum derived nanoparticles represent a group of protein and ion containing small particles that are implicated in a number of pathophysiologic processes.Through their disruption of calc
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Introduction: Serum derived nanoparticles represent a group of protein and ion containing small particles that are implicated in a number of pathophysiologic processes.Through their disruption of calcium homeostasis, nanoparticles have been shown to result in diseases such as kidney stone formation, atheroscloerosis, and cancer metastasis.In the present study, we investigated the ability of nanoparticles to mediate the repair of cutaneous injuries.The healing capacity of nanoparticles was examined by treating injured mice with nanoparticles.Methods: Two circular (8mm diameter) dorsal cutaneous wounds were created on 8 week old female Balb/C mice.Immediately after injury, mice received an injection of 100ul of normal saline or 100ul of nanoparticles via the tail vein.Wounds were analyzed and histological specimens were obtained at various timepoints.Results: The wounds in mice that received treatment with nanoparticles were found to be significantly smaller than the wounds of control mice at all timepoints (including 1 hour post-injury).Histologically, evidence of nanoparticles could be seen in treated mice.Conclusion: Nanoparticles appear to have the ability to traffic to sites of cutaneous injury and increase the rate of wound closure in mice.The exact mechanism by which nanoparticles exert their therapeutic effect is still unknown, and studies are currently ongoing to elucidate this process.The healing potential of nanoparticles has important implications for the field of plastic surgery, as they may allow for rapid closure of chronic non-healing wounds.
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