【摘 要】
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Background, Motivation and Objective Devices for microparticle and cell manipulation have been developed for many biophysical applications. Similar to optical tweezers, tightly focused ultrasound micr
【机 构】
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Department of Electrical Engineering, The Hong Kong Polytechnic University, Hong Kong
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Background, Motivation and Objective Devices for microparticle and cell manipulation have been developed for many biophysical applications. Similar to optical tweezers, tightly focused ultrasound microbeam (acoustic tweezer) has been reported to be capable of manipulating a single microbead. Although previous results suggested that the microbeam device is capable of manipulating particles at the cellular level, it had difficulty in manipulating cells especially non-spherical ones. It is mainly attributed to the gentle intensity gradient around the focus of the microbeam. In order to trap single cells, the f-number (f＃ = focal length / aperture size) of the device must be further reduced in order to allow the microbeam to form the steeper intensity gradient, resulting in much stronger trapping capability. The goal of this research is to develop an acoustic tweezer that can manipulate a single red blood cell (RBC) which is an oval and flexible biconcave disk in ~7 μm diameter. This is for the first time that the utilization of acoustic microbeam for manipulating non-spherical cells is re-ported.
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