Objective: To investigate the influence of different stabilizers on the particle size of glycyrrhetinic acid (GA) nanosuspension during freeze-drying and/or storage, and to obtain the optimal formulat
Multidrug resistance (MDR) is a major obstacle to successful chemotherapy.The mechanisms of drug resistance are incompletely defined, and the most common mechanism involves drug efflux from cancer cel
We prepared innovative polyelectrolyte complex nanoparticles(AAP/LCS NPs), formed by mixing negatively charged auricularia auricular polysaccharide(AAP) with positively charged low molecular weight ch
In this study, we performed the experiments to explore the beneficial effects of Angelic sinensis polysaccharedes (ASP) on hypoglycemic and hypolipidemic in type 2 diabetic Balb/c mice.
A novel oral mucosal vaccine based on microneedle array has been developd to make a highly safe, stable and potent product with good compliance.Firstly two types of liposomes as a vaccine antigen (Ag)
This work described an eco-friendly approach for the synthesis of sliver nanoparticles (AgNPs) with a water-soluble fraction of polysaccharides (AMWP) extracted from the roots ofAstragalus membranaceu
Aims: The 3243A>G mutation of mtDNA usually is associated with MELAS syndrome.In 3243A>G patients, respiratory chain complex Ⅰ deficiency is most frequently found, and partial decreased amounts of com
Background: Autosomal recessive non-syndromic hearing loss (ARNSHL) is highly heterogeneous, and transmembrane channel-like 1 gene is a disease-causing gene.So far, 35 homozygous mutations in TMC1 wer
先天性唇腭裂(Cleft with or without palate,CL/P)是一种常见的生理缺陷,发病率为1∶500-1∶2500,临床表现为唇裂伴有或者不伴有腭裂.唇腭裂具有高度的遗传异质性,可分为综合征型和非综合征型两种类型.其中非综合征型唇腭裂受基因和环境两种因素共同影响,致病基因及分子病理机制尚不清楚.本研究收集了一个四代遗传的非综合征型唇腭裂家系,该家系共有6位患者,其中有2位表现
肺泡微结石症(pulmonary alveolar microlithiasis,PAM)是一种罕见的肺部疾病,以磷酸钙盐颗粒在肺泡内沉积为特征,有家族遗传倾向,多以常染色体隐性方式遗传.PAM患者早期症状不明显,可在30-40岁之间逐渐出现干咳、呼吸困难、咯血、气胸及肺心病等症状.临床上主要通过X线或胸部CT对PAM进行确诊,患者双肺可见弥漫性砂粒样钙化结节影,且随病情进展钙化灶逐渐增多并出现聚