Background:The anterolateral thigh flap has been the workhouse flap for coverage of soft-tissue defects in head and neck for decades.However,the reconstruction of multiple and complex soft-tissue defects in head and neck with multipaddled anterolateralthigh chimeric flaps is still a challenge for reconstructive surgeries.Materials and Methods:Here,a clinical series of 12 cases is reported in whichmultipaddled anterolateral thigh chimeric flaps were used for complex soft-tissue defects with several separately anatomic locations in head and neck.Results: Of the 12 cases,7 patients presented with trismus were diagnosed as advanced buccal cancer with oral submucous fibrosis,2 tongue cancer cases were found accompanied with multiple oral mucosa lesions or buccal cancer,and 3 were hypopharyngeal cancer with anterior neck skin invaded.All soft-tissue defects were reconstructed by multipaddled anterolateral thigh chimeric flaps,including 9 tripaddled anterolateral thigh flaps and 3 bipaddled flaps.The mean length of skin paddle was 19.2(range: 14–23)cm and the mean width was 4.9(range: 2.5–7)cm.All flaps survived and all donor sites were closed primarily.After a mean follow-up time of 9.1 months,there were no problems with the donor or recipient sites.Conclusion:This study supports that the multipaddled anterolateral thigh chimeric flap is a reliable and good alternative for complex and multiple soft-tissue defects of the head and neck.