论文部分内容阅读
FOXM1-mediated Linc-ROR Regulates the Proliferation and Sensitivity to Sorafenib in Hepatocellular C
【机 构】
：
Jinling Hospital
【出 处】
：
2019中国肿瘤学大会
【发表日期】
：
2019年7期
其他文献
Objective Currently the four means of treating cancer are surgery,radiotherapy,chemotherapy and biological therapy.Tumor immunotherapy has become a hotspot of biological treatment.
Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through
Objective Gastric cancer is one of the most common and aggressive cancer types throughout the world.Most gastric cancer associates with dysfunction of the mucosal barrier in the stomach,the first line
目的 胶质瘤干细胞是恶性胶质瘤复发及难治的重要原因。因此，寻找有效的抑制胶质瘤干细胞干性特征的靶向治疗方式，是目前研究的热点。本课题研究的BET 家族蛋白在肿瘤重要的信号分子转录过程中起重要调节作用。
目的 本研究旨在研究EZH2 抑制剂GSK126 诱导胶质瘤细胞自噬性凋亡的分子机制,为靶向EZH2 治疗胶质瘤提供科学依据方法 1.TCGA 数据库中分析EZH2 在胶质瘤组织中的表达以及与胶质瘤患者预后的关系；同时采用western-blot、免疫组化及qPCR 检测临床来源的胶质瘤组织标本中EZH2 的表达情况；2.体外实验中CCK-8 检测EZH2 抑制剂GSK126 对胶质瘤细胞株及原代
Objective Breast cancer is one of the most common cancers in women and has been a major cause for cancer death of women.In clinical work,breast cancer is classified into four molecule subtypes mainly
Objective Melanoma is a rare,but fatal skin tumor,which is consisted of four main types: lentigo maligna melanoma(LMM),superficial spreading melanoma(SSM),nodular melanoma(NM),and acral lentiginous me
目的 第三代芳香化酶抑制剂(aromatase inhibitors,AIs)作为临床上绝经后雌激素受体(ER)阳性乳腺癌患者的一线用药,通过阻断内源性雌激素的产生而抑制癌细胞的失控增殖,其疗效优于他莫昔芬。然而临床上AIs 治疗的有效率仅为25％～45％。
Macrophages reprogrammed by lung cancer microparticles promote tumor development via releasing IL-1β
目的 Despite macrophages are known to contributed for inhibitory immune microenvironment of tumor(tumor associated macrophages,TAMs),the origin and function of TAMs are remaining poorly understood.
Objective Neuroendocrine Carcinoma(NEC)is a malignant cancer which prone to local recurrence and remote metastasis,patients with this type of cancer usually have a poor prognosis and very short overal