【摘 要】
：
Adult hippocampal neurogenesis has been demonstrated in several species and is regulated by both environmental and pharmacological stimuli.Repeated exposure to stress is known to induce the reduction
【机 构】
：
Department of Integrative Medicine and Neurobiology, Shanghai Medical College; Institute of Acupunct
【出 处】
：
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Adult hippocampal neurogenesis has been demonstrated in several species and is regulated by both environmental and pharmacological stimuli.Repeated exposure to stress is known to induce the reduction of neurogenesis in the dentate gyrus.The present study aimed at determining whether the clinically effective antidepressant clomipramine may influence hippocampal proliferation and neurogenesis in adult rats subjected to the chronic unpredictable stress (CUS) procedure,a model of depression with predictive validity.Repeated administration of clomipramine (5 mg/kg i.p.) for 3 weeks,starting 2 weeks after the beginning of the stress procedure,significantly reversed the reduction of behavior measured by open field test and forced swimming test.Moreover,rats subjected to stress exhibited a 49.9% reduction of cell proliferation at the end of a 5-week stress period,an effect which was overcome by clomipramine treatment.These results demonstrated that exposure to CUS,which results in a state of behavioral depression,decreases hippocampal cell proliferation and that these effects can be counteracted by chronic clomipramine treatment.
其他文献
Bis(7)-tacrine [bis(7)-tetrahydroaminacrine]是一种新型的二聚体乙酰胆碱酯酶抑制剂,由两个tacrine分子通过庚烯键连接而成.实验证明它的药效比tacrine强150倍,抑制乙酰胆碱酯酶的选择性是tacrine的250倍.Tacrine是首先用于缓解治疗老年痴呆症(AD)的乙酰胆碱酯酶抑制剂.Bis(7)-tacrine可以有效逆转大鼠AF64A诱导空间
Stroke is one of most critical diseases in nervous system.However,it is still difficult to find a good way for the drug delivery to the ischemic regions because of the blood-brain barrier.It has been
The mature human nervous system faces two main threats to its integrity and function--catastrophic oxygen deprivation and neurodegenerative disease.Currently,there are no widely accepted clinical prot
The development of cocaine addiction involves long-lasting changes in neural plasticity and histone modification has been implicated as a potential mechanism for cocaine-induced alterations of neural
Objective Alzheimers disease (AD) is characterized by overproduction of β amyloid peptides (Aβ) in the brain with progressive loss of neuronal cells.Some studies have showed that Aβ31-35,a shorter act
Alzheimers disease (AD) is the most common neurodegenerative disorders in the central nervous system.Recently,environment factors have been considered a significant contributor for the development of
目的 研究安宫牛黄丸对大鼠脑出血后脑水肿尾壳核水通道蛋白-4 (aquaporin-4,AQP4)表达的影响.方法 将118只SD大鼠随机分为安宫牛黄丸治疗组(AGNHW治疗组,n=36)、脑出血组(ICH组,n=36)、假手术组(n=36).每组分为术后12h、1d、2d、3d、5d和7d六个时点,每个时点6只大鼠,正常对照组10只大鼠.采用自体股动脉血注入尾状核建立大鼠脑出血模型,分别用干湿重
目的 探讨脑缺血大鼠大脑皮质和海马CA1区BBB超微结构和通透性的变化规律.方法 选用成年健康雄性SD大鼠45只,体重200-350 g,随机分为正常对照组、假手术组和全脑缺血10 min、20 min、30 min组.参照Pulsinelli-Brierley方法制作脑缺血动物模型,并按模型评价标准选择建模成功动物；假手术组仅电凝闭塞双侧椎动脉,不夹闭双侧颈总动脉.(1)组织学观察BBB：到期动
Objective To determine whether oligodendrocyte precursor cells (OPCs) are appropriate for axonal regeneration and whether the ability of OPCs in promoting axonal regeneration is a result of lack of ex
As an extreme form of abnormally synchronized activity,epilepsy may modify patterns of organization in the nervous system.It is clear that enhanced glutamatergic excitatory synaptic transmission with