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  5. HPLC assay validation for KCNQ/M-channel opener QO58-lysin in rat plasma and Its application to phar

HPLC assay validation for KCNQ/M-channel opener QO58-lysin in rat plasma and Its application to phar

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：caoyufeiyu
【摘 要】
：
The voltage-gated KCNQ/M-potassium channels play a principal role in controlling neuronal excitability.Mutations or inhibition of KCNQ/M-channels can cause neurological diseases, such as myokymia and
【作 者】
：
Tian-yang MA Bo-chuan TENG Jin-long QI Hai-lin ZHANG Ke-wei WANG 
【机 构】
：
Department of Molecular and Cellular Pharmacology, State Key Laboratory of Natural and Biomimetic Dr
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
KCNQ opener QO58-lysin HPLC pharmacokinetics 
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The voltage-gated KCNQ/M-potassium channels play a principal role in controlling neuronal excitability.Mutations or inhibition of KCNQ/M-channels can cause neurological diseases, such as myokymia and bernign familial neonatal convulsions.Therefore, development of specific KCNQ2/3 channels openers may provide a therapeutic strategy for treatment of neuronal excitability disorders.
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