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  5. A novel chitosan copolymer and its nanoparticles for Mitoxantrone delivery

A novel chitosan copolymer and its nanoparticles for Mitoxantrone delivery

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：ananjuben
【摘 要】
：
A novel biodegradable amphiphilic copolymer based on chitosan, poly(lactide) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE)(chitosan co--PLA-DPPE) has been successfully synthesized.In ord
【作 者】
：
Yinghua Liu Min Li Jiakun Zhang Xin Wang Yan Wu 
【机 构】
：
Institute of Material Science and Engineering,Ocean University of China,Qingdao 266100,P.R.China
【出 处】
：
International Conference on Nanoscience & Technology,China 2
【发表日期】
：
2013年3期
【关键词】
：
Chitosan Poly (lactide) 1 2-dipalmitoyl-sn-glyeero-3-phosphoethanolamine Mitoxan 
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论文部分内容阅读
　　A novel biodegradable amphiphilic copolymer based on chitosan, poly(lactide) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE)(chitosan co--PLA-DPPE) has been successfully synthesized.In order to estimate the feasibility as drug carriers, an anti-tumor model drug mitoxantrone (MTO) was incorporated into polymeric nanopartieles by double emulsion and nanoprecipitation methods.Fluorescence spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM) confirmed the formation of chitosan-co-PLA-DPPE nano-sized micelles.
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