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American ginseng extract (AGE) has been shown to have a lot of beneficial effects on disorders of central nervous system.In this paper, the neuroprotective effect of AGE on neurodegenerative disease in rats and the potential mechanism were investigated.AGE was orally administered at 3, 6, 12 mg·kg-1 once daily for 3 weeks.The levels of striatal dopamine (DA), aecorbic acid (AA)and hydroxy radical (·OH) were measured by using high performance liquid chromatography (HPLC) with electrochemical detection.The results showed that AGE markedly prevented the depletion of striatal DA and AA in rats with neurodegenerative disease.On the contrary, the elevated level of · OH was reduced significantly in AGE treated group rats.We suggest that AGE has neuroprotective effect probably via inhibiting the formation of· OH and stimulating the release of endogenous antioxidant.