To investigate the neuroprotective effects of neurotrophin-3(NT-3) expression controlled by five copies of the hypoxia-responsive elements(5HRE)after focal cerebral ischemia.
Our previous study has proved that the up-regulation of glial glutamate transporter 1(GLT-1)induced by cerebral ischemic preconditioning(CIP)played an important role in the acquisition of brain ischem
Neuregulin receptor degradation protein-1(Nrdp1)is an E3 ubiquitin ligase that regulates the proteasomal degradation and activity of proteins involved in cell growth,inflammation and apoptosis,includi
As a therapeutic strategy,remote ischemic postconditioning holds great promise for ischemic stroke,but the underlying mechanisms yet remain unclear,hindering its translation from bench to beside.
MicroRNA-99a(miR-99a) has been reported to function as a tumor suppressor through regulating cell cycle and apoptosis.But its clinical significance in ischemic stroke and its function in cerebral isch
Mammalian cortical expansion is tightly controlled by fine-tuning of proliferation and differentiation of neural progenitors in a region-specific manner.
Objective Long-term potentiation(LTP)of synaptic transmission is thought to be a direct reflection of synaptic information storage and synaptic plasticity,which is closely related to learning and memo