Objective: To investigate the dynamic expression of vascular endothelial growth factor (VEGF) and angiopoietin-2(Ang-2), and antiangiogenic therapy on hepatocyte malignant transformation.Methods: Hepatoma models were induced with 2-fluorenylacetamide(2-FAA) on male Sprague-Dawly rats; thalidomide was administered intragastrically (100 mg/kg body weight) to intervene HCC progress.A part of rats were sacrificed fortnight interval for 12 weeks.Morphological changes ofhepatocyte were observed by H&E staining.VEGF expression was analyzed by immunohistochemistry, and its level was quantitatively detected by enzyme linked immunosorbent assay or byWestem blotting.