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5. Less is more:design of highly stable disulfide-deleted analogues of α-conotoxins

Less is more:design of highly stable disulfide-deleted analogues of α-conotoxins

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：underdog1234

【摘 要】

：

Cyclic α-conotoxin Vc1.1(cVc1.1)(Fig 1)is an orally active peptide with analgesic activity in rat model of neuropathic pain [1].cVc1.1 has two disulfide bonds,which can have three different connectivi

【作 者】

：

R YU N TABASSUM V SEYMOUR G BERECKI X JIA M AKCAN DJ ADAMS Q KAAS DJ CRAIK T JIANG 

【机 构】

：

Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean U

【出 处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Conotoxins peptide stabilization molecular dynamics simulation nuclear magnetic 

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　　Cyclic α-conotoxin Vc1.1(cVc1.1)(Fig 1)is an orally active peptide with analgesic activity in rat model of neuropathic pain [1].cVc1.1 has two disulfide bonds,which can have three different connectivities,one of which is the native and active form.

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