Infectious pathogens often cause serious economic loss and public health concerns throughout the world.One important characteristic of infectious diseases is that they often occur in high-poverty regions, where people cannot afford expensive and bulky equipment.Although numerous polydimethylsiloxane (PDMS) and paper-based microfluidic devices have been developed to address this issue, PDMS/paper hybrid systems that take advantage of both substrates are rarely reported.Each device substrate has its own advantages and disadvantages.