【摘 要】
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Objective HER2(+) breast cancer responds well with trastuzumab treatment.However, more than 60%-80% of HER2(+) breast cancers develop trastuzumab-resistance after one year treatment.Previous studies s
【机 构】
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State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Chinese Academy of Medical
【出 处】
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2015诺贝尔奖获得者医学峰会暨国际肿瘤研究高峰论坛
论文部分内容阅读
Objective HER2(+) breast cancer responds well with trastuzumab treatment.However, more than 60%-80% of HER2(+) breast cancers develop trastuzumab-resistance after one year treatment.Previous studies showed that more than 50% of HER2(+) trastuzumab-resistant breast cancers have PTEN deletion and increased populations of cancer stem cells (CSCs).The purpose of this study is to explore novel targets to regulate cancer stem cells and to test treatment option for HER2 (+) trastuzumab-resistant breast cancers.
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