Kinases play pivotal role play pivotal roles in virtually all aspects of cellular physiology1.Potent and selective kinase inhibitors are highly desirable,both as tool compounds for dissecting complex signaling pathways and as potential therapeutics for treating kinase-related diseases.Hence there is an urgent need to develop methodologies that will allow for the rapid identification of kinase inhibitors of interest.Compound centric kinome-wide profiling enables rapid discovery of the full range of kinase-targets for a particular scaffold2.