【摘 要】
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Purpose:To determine the suitability of porous silicon photonic crystals for long-lasting intraocular drug-delivery.Methods:A rugate structure was electroch
【机 构】
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The Institute of Ocular Pharmacology School of Ophthalmology and Optometry Wenzhou Medical College C
【出 处】
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中国上海第七届国际新药发明科技年会
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Purpose:To determine the suitability of porous silicon photonic crystals for long-lasting intraocular drug-delivery.Methods:A rugate structure was electrochemically etched into a highly doped p-type silicon substrate to create a porous silicon film that was subsequently removed and ultrasonically fractured into particles.To stabilize the particles in aqueous media,the silicon particles were modified by surface alkylation (using thermal hydrosilylation) or by thermal oxidation.Unmodified particles,hydrosilylated particles and oxidized particles were injected into rabbit vitreous.The stability and toxicity of each type of particle were studied by indirect ophthalmoscopy,biomicroscopy,tonometry,electroretinography (ERG) and histology.The daunorubicin was covalently attached to the Psi film and in vitro release study was performed.
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