肠道病毒71型2C蛋白通过结合RelA(p65)抑制NF-κB通路激活的研究

来源 :第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会 | 被引量 : 0次 | 上传用户：pp

【摘要】

：

病毒采用多种策略抑制NF-κB信号通路以利于自身复制。肠道病毒71型是引起手足口病的首要病毒。本文中通过酵母双杂交鉴定NF-κB信号通路关键因子RelA(p65)与肠道病毒71型2C蛋白存在相互作用。进一步实验表明,通过结合p65的IPT区段,2C能够抑制p65/p50的异源二聚体的形成。同时,小RNA病毒科多种病毒的2C蛋白通过结合p65以及IKKβ进而抑制NF-κB通路激活。综上,本文为肠道病

【作者】

：

杜海威殷佩齐张磊亮金奇

【机构】

：

中国医学科学院/北京协和医学院病原生物学研究所卫生部病原系统生物学重点实验室,北京市 100176

【出处】

：

第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会

【发表日期】

：

2015年6期

【关键词】

：

肠道病毒71型 NF-κB 2C

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肠道病毒71型2C蛋白通过结合RelA(p65)抑制NF-κB通路激活的研究

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