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Discipline development of pharmacometrics (PM)Based on traditional pharmacokinetics 1977: Sheiner, Population pharmacokinetics 1980: NONMEM 1980s: Discipline start 1991: Population pharmacokinetics (Author Keywords) 1997: Pharmacometrics (Author Keywords) Aim of PM discipline analysis Review the history of PM development Analysis of the feature and trend of PM research Comparison the research cores among different stages