Background Patients of chronic hepatitis B with acute exacerbation were usually followed by a spontaneous decline of HBV DNA.The subsequential antiviral therapy are controversial.In this study, we eva
Background Standard therapy for CHC still faces many unmet medical needs.T.C.M.exhibit liver function protection, anti-fibrosis, immune function modulation and some extent anti-viral function in CHC t
Introduction Hepatocellular carcinoma (HCC) is the third most common cause of death worldwide.The risk of developing HCC in patients suffering from cirrhosis is increased in the setting of chronic HCV
Background Depression, a common side effect of interferon therapy in patients with chronic hepatitis C, is closely associated with antiviral dosage reduction, discontinuation and failure of treatment.
Aim uncover the possible immune response to HBV naked core particle in hydrodynamic injection mice model.Methods Plasmids expressing wild type of HBV core protein (HBcWT), or HBcK96R mutation which ab
Hepatitis B virus (HBV) polymerase (pol) gene has been demonstrated to play an important role in the progression of liver disease and in fulminant hepatitis.Previous studies from our laboratory have s
原发性肝癌恶性程度高,起病隐匿,病情进展快,容易复发转移;而且我国肝癌多发生在肝炎、肝硬化基础之上,不仅造成机体的损伤,还降低肝脏的储备功能,严重影响肿瘤的治疗和预后.肝癌的治疗不仅需关注消除肿瘤本身,而且必须同时注重保护患者肝功能、减少肝功能损害.肝癌规范治疗的最主要评价标准是患者生存获益.
Background Clinical use of bioartificial liver (BAL) strongly relies on the development of human liver cell lines.The aim of this study was to establish and assess the potential usage of the HepG2 cel
Background & Aims The woodchuck model is an informative model for studies on hepadnaviral infection.In this study, woodchuck hepatitis virus (WHV) transgenic (Tg) mouse models based on C57BL/6 mice we
We have previously shown that polyinosinic-polycytidylic acid (poly (I ∶ C)) activates murine hepatic cells to produce interferon (IFN) and suppresses HBV replication in vitro.Therefore, we addressed