Evans syndrome (ES) is a rare combination of autoimmune hemolytic anemia and thrombocytopenia.This case report details an old male ES patient with acute myocardial infarction.He was successfully treated by primary percutaneous coronary intervention in the case of low hemoglobin level (60 g/L).Considering ES recurrence after surgery, he was given human immunoglobulin, methyl prednisolone and TPO treatment.Both anemia and thrombocytopenia were caused by abnormal autoimmune reaction, but their changes were found not parallel.On the basis of his platelet count, the patient was required to take only one anti-platelet drug or stop all anti-platelet drugs.To the best of our knowledge, this is the first report of ES with AMI.This case suggests that primary PCI can be a useful therapeutic strategy even if patient has low hemoglobin level, but careful balance between anti-platelet therapy and efforts to raise platelet count are needed after surgery.