【摘 要】
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Objective:To assess the effect of treatment with a combination of the tamoxifen citrate and testosterone undecanoate on sperm variables in men with idiopathic azoospermia or oligozoospermia.Design:Ret
【机 构】
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Guangdong Key Lab.Male Reproductive Medicine & Genetics,Shenzhen Hospital,Peking
【出 处】
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中华医学会生殖医学分会人类精子库管理学组第三届年会暨全国男性生殖医学和精子库管理新进展第四次研讨会
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Objective:To assess the effect of treatment with a combination of the tamoxifen citrate and testosterone undecanoate on sperm variables in men with idiopathic azoospermia or oligozoospermia.Design:Retrospective,self control trial.Participants:four men with idiopathic azoospermia and eight men with idiopathic oligozoospermia Interventions:All patients were treated with testosterone undecanoate,80mg/d and tamoxifen citrate,20mg/d.Couple counseling was part of the intervention in all participants.Main Outcome Measure(s):Sperm characteristics and pregnancy incidence every month after 1 and 4 months medication.Result(s):Tamoxifen citrate plus T undecanoate treatment produced a satisfactory improvement of total sperm number,motility after 2 and 3 months whereas FSH,LH in serum increased after treatment.Conclusion:These results indicate that the combination of tamoxifen citrate with T undecanoate could improve significantly sperm count.The combination deserves a place as a first line of treatment in spermatogenic arrest.
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