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Objectives Compared against the clinical usage,animal models for Polygonum multiflorum Thunb -induced liver injury cost quite a long period up to 1 or 3 months with 200 times the clinic dosage.This study is to establish an early-warning animal model to investigate its potential mechanism,and to verify the effectiveness of serum microRNA-122 as a candidate biomarker for Drug-induced Liver Injury(DILl).