肝癌中c-Myc介导的microRNA-101表观沉默机制及功能研究

来源 :第八届全国医学生物化学与分子生物学、第五届全国临床应用生物化学与分子生物学、2013华东六省一市生物化学与分子生物学联合 | 被引量 : 0次 | 上传用户：blueskyjava

【摘要】

：

癌基因c-Myc在肿瘤的发生发展过程中起重要作用,大量的研究表明,肝癌细胞中c-Myc处于异常高表达的状态,并能够广泛地抑制众多抑癌miRNA分子的表达;然而c-Myc沉默这些miRNA分子的分子机制还有待阐明.本研究研究目在于解析肝癌细胞中c-Myc蛋白沉默miR-101表达的分子机制,分析miR-101新的下游靶分子及其生物学功能.

【作者】

：

王磊张瑞杨安钢

【机构】

：

第四军医大学生物化学与分子生物学教研室,西安710032 第四军医大学免疫学教研室,西安71003

【出处】

：

第八届全国医学生物化学与分子生物学、第五届全国临床应用生物化学与分子生物学、2013华东六省一市生物化学与分子生物学联合

【发表日期】

：

2013年2期

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