Controllable drug delivery has attracted wide interest in biomedicine and other fields of science in order to achieve a targeted use of an active substance at the right time and the right place.Three-dimentional(3D)semiconductor arrays have attracted tremendous scientific interest due to the combination of geometric features with an inherent photocatalytic activity.In this context,we prepared amphiphilic TiO2 nanotube arrays by a two-step anodization procedure.By utilizing the photocatalytic ability or voltage-induced carrier generation of TiO2,a precisely controlled removal of the cap and a highly controlled release of hydrophilic payload(drug)can be achieved.However,many biomolecules suffer from denaturation or disintegrate when long-term irradiated by UV light.To overcome this challenge,we introduce the photocatalytic chain scission of organic monolayers attached to TiO2 nanotubes under visible light by using Au-SPR-TiO2 coupling.This allows eliminating hydrophobic caps on TiO2 nanotubes and causing efficient release of loaded hydrophilic payloads.We demonstrate that ampicillin sodium(AMP),can be released in a highly controlled manner and antibacterial tests confirm that the activity of the released drug is maintained.We believe that the underlying trigger mechanism can be used in other large band-gap semiconductors to achieve promising visible-light photocatalysis applications.