Inhibition of PAI-1 rescues the defect in ischemia-induced neovasculature in type Ⅱ diabetic mice

来源 :微循环国际研讨会暨第十三届全国中西医结合微循环学术会议(International Conference for Mic | 被引量 : 0次 | 上传用户：oncle

【摘要】

：

【作者】

：

Rong Li Xiao Zhang Mei-Ping Ren Mao Luo Kai Yan Jian-Bo Wu

【机构】

：

Drug Discovery Research Center,Luzhou Medical College,Luzhou,Sichuan,China

【出处】

：

微循环国际研讨会暨第十三届全国中西医结合微循环学术会议(International Conference for Mic

【发表日期】

：

2013年2期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Objective-Type Ⅱ diabetes mellitus (DM) leads to the development of microvascular diseases and is associated with impaired angiogenesis.Elevated plasma levels of plasminogen activator inhibitor-1 (PAI-1) are associated with DM.However, the role of PAI-1 in the development of DM-associated vascular disease is poorly defined.

其他文献

Platelet Apoptosis in Uremic Patients

Introduction: Apoptosis, which serves for the regulation of cell lifespan and is long attributed exclusively to nucleated cells, has been well-documented in anucleate platelets.Diverse cell-external c

会议

Surface Expressions of Platelet Glycoprotein Ibα, GpⅡb/Ⅲa, and P-Selectin Are Elevated in Lung Cance

Objective: Thromboembolic events are common symptoms in patients with cancer, and the mechanisms are not totally understood.The platelet adhesion molecules play important roles in the process of throm

会议

miR30c regulates plasminogen activator inhibitor-1 in platelet

Objective PAI-1 mRNA and protein have been detected in human platelets.Recently some miRNAs have been found in human platelets, which are involved in the regulation of genes and the protein synthesis.

会议

Nitric oxide is involved in the regulating of lymphatic reactivity following hemorrhagic shock

Objective: To investigate the effects of Nitric oxide (NO) on the shock-induced biphasic change in lymphatic reactivity and the related mechanism.Methods: The contents of NO, cyclic adenosine monophos

会议

Aspirin Induces Platelet Apoptosis

Aspirin is widely used in the treatment of a number of clinical conditions, such as fever, pain, strokes, and heart attacks.Although aspirin is being thought of a relatively "safety" medicine, it also

会议

Post-hemorrhagic shock mesenteric lymph is involved in cardiac dysfunction following hemorrhagic sho

Objective: The present study was designed to evaluate whether post-hemorrhagic shock mesenteric lymph (PHSML) involved in cardiac dysfunction following hemorrhagic shock.Methods: The hemorrhagic shock

会议

Role of hydrogen sulfide on post-hemorrhagic shock mesenteric lymph drainage alleviating multiple or

Objective: To investigate the role of hydrogen sulfide (H2S) on post-hemorrhagic shock mesenteric lymph (PHSML) drainage alleviating multiple organ injury in rats, by administering D,L-propargylglycin

会议

Role of myosin light chain kinase on post-hemorrhagic shock mesenteric lymph blockade ameliorating t

Objective: To explore whether myosin light chain kinase (MLCK) involves in the post-hemorrhagic shock mesenteric lymph (PHSML)-mediated vascular hyporeactivity and calcium desensitization in rats.

会议

Kudiezi injection adjust PKC δ/MARCKS signal pathway and protect vascular endothelial cells after hy

Objective: The present study was designed to evaluate whether Kudiezi injection was beneficial for vascular endothelial cells after hypoxia injury and prove the role of PKC δ/MARCKS signal pathway on

会议

Inhibition of NADPH oxidase mediates protective effect of cardiotonic pills(R) against rat heart isc

Cardiotonic pills(R) (CP) is a compound Chinese medicine currently used in China for treatment of ischemic angina pectoris.Our previous results indicated that a single dosing of CP pretreatment at 0.8

会议

Inhibition of PAI-1 rescues the defect in ischemia-induced neovasculature in type Ⅱ diabetic mice

与本文相关的学术论文