【摘 要】
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Appropriate regulation of the response to stress is critical for the maintenance of homeostasis.In mammals, the response is mediated by the hypothalamic-pit
【机 构】
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Department of Pharmacology and Neuroscience Institute for Aging and Alzheimer's Research Health Ins
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Appropriate regulation of the response to stress is critical for the maintenance of homeostasis.In mammals, the response is mediated by the hypothalamic-pituitary-adrenal axis (HPA axis).In response to stressful stimuli, neurons in the paraventricular nucleus (PVN) of the hypothalamus synthesize and secrete cortiocotropin-releasing factors, the most potent of which is CRH.Secretion of CRH ultimately leads to secretion of glucocorticoids.Although beneficial in the short run, elevated levels of circulating glucocorticoids for prolonged periods leads to adverse effects such as immunosuppression and osteoporosis.
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