目的:超极化激活环核苷酸门控阳离子通道(HCN)参与心脏起搏,疼痛,癫痫等生理病理活动.在人类的窦房结(SAN),HCN4是HCN家族的中最丰富的亚型,而且自2003年起,对HCN4基因几个失去功能的突变体的研究表明,HCN4与窦房结功能障碍关联重大.因此HCN通道阻滞剂是在心脏疾病的治疗的新方法,如伊伐布雷定被批准用于治疗稳定型心绞痛.本论文旨在构建超极化激活环核苷酸门控阳离子通道(HCN)亚型
Objective: Influenza is one of the major global plagues, and to date there are only two types of effective antiviral agents against it in clinic (M2 inhibitors and NA inhibitors).
Morusin is a prenylated flavonoid that was firstly isolated from the root bark of Morus alba L., possesses anti-HIV, anti-oxidant, anti-inflammatory and anti-tumor activities.
Background: Filamentous microorganisms such as filamentous fungi and bacteria are represented as one of the major sources for bioactive compounds, especially for lead identification in medical science
Semen-derived enhancer of viral infection(SEVI), made up of residues 248-286 of prostatic acidic phosphatase (PAP248-286), is composed of amyloid fibrils that can greatly enhance HIV-1 infectivity and
Influenza virus remains to pose a direct threat to human beings and society for causing severe epidemics of respiratory illness, and highlights an urgent need for new anti-influenza drugs.
Although the current combined anti-retroviral therapy (cART) could successfully control HIV viraemia in infected patients under the detectable level, it fails to completely eradicate the pathogen.
目的:目前尚无低剂量131I用于治疗低刺激性Tg、不伴有远处转移的高危分化型甲状腺癌的相关研究,本研究旨在探讨低剂量131I在这部分人群中的清甲效果.方法:纳入本回顾性研究的标准为:1)年龄＞18岁;2)分化型甲状腺癌全切术后;3)T4分期(术中肉眼可见甲外侵犯),任何N分期;4)清甲治疗前刺激性Tg≤5ng/ml;5)无远处转移的证据;6)TgAb≤46IU/ml.这部分患者在TSH刺激状态下(
Objective: AZD9291 is an oral, potent, irreversible EGFR-TKI, selective for sensitizing (EGFRm+) and T790M resistance mutations, currently under investigation in an ongoing Phase Ⅰ study of pts with E
Objective: Dacomitinib (D) is an irreversible pan-HER kinase inhibitor.The ARCHER 1009 global phase Ⅲ study compared D and erlotinib (E) as treatment for locally advanced/metastatic non-small cell lun