Nanoparticle materials with modification are good for serving as shuttles of drug delivery and contrast agents in different biomedical imaging modalities such as magnetic resonance imaging (MRI),computed tomography (CT),ultrasound tomography,positron emission tomography (PET),and optical imaging based on their special properties in magnetism,acoustics,optics,and electrics [1].Here we show nanoparticle materials of Gd2O3,Fe3O4,or TiO2 and their composites acting as shuttles of drug delivery and contrast agents in MRI for cancer.In this presentation,according to our new data,we will show that metal oxides-based nanoparticles could act as imaging agents [2] and therapeutic agents for cancer cells [3,4],or overcome multidrug resistance in human breast cancer cells,or target to cancer and decrease the cytotoxicity along with biomedical imaging.In future,we might use these nanoparticle materials not only localize the cancer/diseases area acting as contrast agents in biomedical imaging,but also target and treat the cancer/diseases acting as therapeutic agents simultaneously.