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Nonalcoholic fatty liver (NAFL) is increasingly recognized as one of the most common cause of chronic liver disease worldwide.Traditional Chinese Medicine (TCM), as the alternative and complementary medicine, may provide some profound health benefit.Jiang-Zhi Granule (JZG) was composed based on TCM pathogenesis of NAFL-the retention of inner dampness, heat and blood stasis.This study investigated effects of JZG on liver X receptor-α (LXRα)/Sterol regulatory element binding protein-1c (SREBP-1c) pathway in high-fat diet (HFD)-induced hepatic steatosis, as well as in rice fatty acid (FFA)-and T0901317-treated HepG2 cells.The results showed that JZG had an anti-steatotic effect in HFD-fed rats.JZG decreased the activation of SREBP-1c through inhibiting LXRα-mediated SREBP-1c transcription, as well as through inhibiting the maturation of SREBP-1c independent of LXRα.These findings may provide molecular evidence for the use of JZG as a promising therapeutic option for NAFL, and support us to continue JZG treatment in NAFL.For JZG treatment to be widely accepted, a randomized, double-blind, multicenter,placebo-controlled, phase Ⅲ trial is ongoing.