Whether a drug-resistant pathogen can be labeled as a MDRO is based on its clinical & medical relevance, including 1) the extent of antibiotic resistance (2 antibiotics? 3 antibiotics? ＞ 4 antibiotics?) 2) The available therapies 3)The infections and disease syndromes caused 4)The medical impact (morbidity & mortality & cost) 5)The potential ability to control its spread.