【摘 要】
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OBJECTIVE To evaluate and compare the of Losartan and Losartan/Hydrochlorothiaside combination tablets in healthy chinses male volunteers.METHODS Both studies were open, randomised, single-dose studie
【机 构】
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Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan 250012, China
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OBJECTIVE To evaluate and compare the of Losartan and Losartan/Hydrochlorothiaside combination tablets in healthy chinses male volunteers.METHODS Both studies were open, randomised, single-dose studies in healthy volunteers.Twenty healthy chinese male volunteers were given a single-dose 50 mg losartan tablets, and other twenty ones were given a single-dose 50 mg losartan/12.5 mg hydrochlorothiazide combination tablets, respectively.A LC-MS method was used to determine the concentration of losartan, E3174 and hydrochlorothiazide in plasma up to 48 h after oral administration, and the pharmacokinetics were calculated.The were obtained via these tests.RESULTS Pharmacokinetic parameters for Losartan and its metabolites E3174 were similar for the combination and monotherapy tablets except for the AUC0-t and T1/2 from the montherapy, which was opposite with combination.The rate of elimination of E3174 (T1/2) was significantly faster and the AUC0-t was lower (P < 0.05), when the combination was adminis-teration.
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