【摘 要】
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Tumor necrosis factor (TNF)-α and interferon (IFN)-γare the major pro-inflammatory cytokines involved in beta-cell destruction.The fate of islet beta-cells in the cytokine-induced intrinsic mitochondr
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Tumor necrosis factor (TNF)-α and interferon (IFN)-γare the major pro-inflammatory cytokines involved in beta-cell destruction.The fate of islet beta-cells in the cytokine-induced intrinsic mitochondrial apoptotic pathway is determined by the interaction between members of the Bcl-2 family.However, the mechanism through which beta-cell apoptosis is regulated remains unclear.In this study, we induced beta-cell apoptosis with TNF-α and IFN-γ treatment in a murine beta-cell line NIT-1.
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