Chidamide: a novel epigenetic therapy as an effective single-agent treatment in patients with relaps

来源 :22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会) | 被引量 : 0次 | 上传用户:lhchg1982
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Objective: To evaluate chidamide efficacy and safety in relapsed or refractory peripheral T-cell lymphoma (PTCL) in Chinese patients.Methods: Exactly 102 PTCL patients were enrolled.In the exploratory triai, patients were randomized to receive 30 or 50 mg chidamide twice per week for two weeks, followed by one week rest.In the pivotal trial, chidamide was administered 30 mg twice per week w/o drug-free day.The primary endpoint was the overall response rate (ORR).Responses were assessed using IWC criteria.
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