【摘 要】
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The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic target.However,relief of feedback inhibition and enhancement of other survival pathways often attenuate anti
【机 构】
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State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou,China
【出 处】
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2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议
论文部分内容阅读
The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic target.However,relief of feedback inhibition and enhancement of other survival pathways often attenuate anticancer effects of AKT inhibitors.In this study,we found a novel 2-pyrimidyl-5-amidothiazole compound,DC 120,as an ATP competitive AKT1 kinase inhibitor,suppressed proliferation and induced apoptosis in liver cancer both in vitro and in vivo.
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