Clinical Development of Cell and Gene Therapy for Cartilage Regeneration in Severe Osteoarthritis Pa

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  TG-C is an allogeneic cell therapy involving human chondrocytes that have been genetically modified to produce the therapeutic growth factor TGF-β1 and has been developed to induce cartilage regeneration in patients with osteoarthritis.Chondrocytes, when stimulated by the transforming growth factor beta 1 (TGF-β 1), have been shown to play a critical role in both the formation and maintenance of articular cartilage by regulating the homeostasis of the hyaline cartilage matrix.
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