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Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids (AA) to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles in the treatment of cardiovascular diseases, but little is known about its role on adventitial remodeling.In this study, the effects of CYP2J2 and its metabolites EETs on Angiotensin (Ang) Ⅱ-induced adventitial remodeling were investigated in vivo and in vitro.CYP epoxygenases/soluble epoxide hydrolase (sEH) system was found to exist in human and mice adventitia, and moreover was activated in adventitial remodeling process.