【摘 要】
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Both the delta-opioid receptor (DOR) and brain-derived neurotrophic factor (BDNF) are neuroprotective against hypoxic/ischemic injury.However, the mechanisms underlying their actions are not clearly u
【机 构】
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The University of Texas Medical School at Houston USA
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Both the delta-opioid receptor (DOR) and brain-derived neurotrophic factor (BDNF) are neuroprotective against hypoxic/ischemic injury.However, the mechanisms underlying their actions are not clearly understood.Moreover, it is unknown if they interact with each other in the neuroprotective process in the brain.Recently, we have explored these aspects and found that DOR up-regulates BDNF signal pathway thereby attenuating the hypoxia-induced inflammatory reaction in the cortex following exposure to prolonged hypoxia.Similar regulatory signal pathway is also found in the astrocytes.This presentation will show an overalI view of advanced research in this filed.
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