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studies have reported mefformin, an insulin-sensitizer drug commonly used for type 2 diabetes, could enhance differentiation and mineralization of osteoblasts in cell culture.However, its roles in osteoclastogenesis are not konwn.In this study we examined the effects of metformin on differentiation and function of osteoclasts and the involvement of mammalian target of rapamycin (mTOR) signaling, one of its targets in this process.