This study presents a fabrication process of bone scaffold model with titanium biomedical materials by three dimensional printing technique.A home-made selective laser sintering (SLS) machine with Nd∶YAG laser was developed to produce bone scaffolds using a layer additive processing technology.The slurry state of biomedical material consists of titanium powder and silica sol mixed at 65∶35 wt% was used in the proposed process.This biomedical titanium-ceramic slurry was solidified after scanning by a laser beam.The scan power, scan speed, and frequency rate of laser are controlled for sintering biomedical slurry.In this study, the process parameters of laser were tuned at a laser power of 15W, a frequency of 16KHz and a scanning speed of 100mm/s to build the titanium biomedical bone model within 3hrs.Experimental results show that the tensile strength is 0.72 MPa and compressive strength is 96 MPa after post heat treatment process.It is confirmed that a bio-metal bone scaffold with complex structure and shape can be constructed by this layer additive processing.The numbers of cell attached on surface of bio-metal bone scaffold is obtained by in vitro cells test.Therefore, this process has a greater potential for fabrication bio-metal bone scaffold in tissue engineering.