【摘 要】
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Spiella maindroni ink polysaccharide,namely SIP,is isolated from the ink of cuttlefish Sepiella maindroni.SIP is a polysaccharide with a molecular weight ab
【机 构】
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KeyLaboratoryofChemicalBiology(MinistryofEducation),InstituteofBiochemicalandBiotechnologicalDrugs,S
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Spiella maindroni ink polysaccharide,namely SIP,is isolated from the ink of cuttlefish Sepiella maindroni.SIP is a polysaccharide with a molecular weight about 1.13× 104 Da and its repeating unit is composed of fucose,N-acetylgalactosamine and mannose in a molar ratio of 2∶2∶1,with a single branch of glucuronic acid at the C-3 position of mannose[1].After sulfation with the chlorosulfonic acid method,SIP-SⅡ,a sulfated derivative of SIP was obtained,and it showed significant anti-metastasis activity at non-toxic concentrations both in vitro[2]and in vivo[3].Furthermore,SIP-SⅡ has been manifested to inhibit tumor growth in S180-bearing mice significantly and alleviate the immunosuppression caused by cyclophosphamide[4].The uncertainty of the anti-metastasis mechanism of SIP-SⅡ hindered its development.Thus,in this study,the action target of SIP-SⅡ and the mechanism of its inhibitory activity on the migration and invasion were investigated.
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